Hi @albert-pender_6390 ,
This is an internal Windows Error, and happens when another process (usually a UI window) has an open session to hive within the Windows Registry. It's a long-standing bug/issue with COM+ services (which Active Directory uses), and is not really ProGet specific.
It's a side-effect of the ProGet upgrade process, which often stops/starts Windows Services and IIS Application pools. Ultimately restarting will fix it (as you've notcied), but changing the "Load User Profile" to "true" on the application pool is also known to fix it as well.
Best,
Alana